TLC's female-focused programming mainly includes reality series about untraditional lifestyles, weddings, relationships, families and life transformations.

A second UK series called Say Yes to the Dress Lancashire, hosted by celebrity stylist Gok Wan launched in Australia and New Zealand in September 2019.

In October 2016 a local version of the franchise, Say Yes to the Dress: Australia launched in both countries and was hosted by Adam Dixon.

Other well-known names to appear on the channel include UK celebrity Katie Price with her series Katie Price: My Crazy Life and Geordie Shore's Vicky Pattison, with the one-hour documentary special Vicky Pattison: The Break Up.

[5] [6] On 1 September 2015, Sky TV New Zealand launched TLC on Sky 016 as part of a wider reshuffle of Sky Channels [7] Say Yes to the Dress: Australia, an international adaptation of the Say Yes to the Dress format from the United States, featuring couture wedding gown designer Adam Dixon, will become the first local production on the channel when it debuts in 2016.