East-southeast of central Memphis, the 18-hole championship golf course was designed by Ron Prichard, in consultation with tour pros Hubert Green and Fuzzy Zoeller.

TPC Southwind opened in 1988, and is a member of the Tournament Players Club network operated by the PGA Tour.

TPC Southwind was the venue for the tour's annual FedEx St. Jude Classic, formerly the Memphis Open, for three decades (1989–2018).

[4] In 2019, FedEx took over sponsorship of the WGC Invitational and relocated it to Memphis, played at TPC Southwind in late July.

With 94 bunkers and ten water hazards, TPC Southwind was ranked ninth in difficulty out of 51 courses on the PGA Tour in 2011.