HC TSV Bayer 04 Leverkusen is a Germany professional women's handball club from Leverkusen representing TSV Bayer 04 Leverkusen in the Handball-Bundesliga Frauen.

Bayer Leverkusen won six national championships between 1965 and 1980, and six more titles in a row between 1982 and 1987, its most successful period.

It was the only team from West Germany to reach the European Cup's final before the country's reunification, in 1984,[1] and seven years later it also played the EHF Women's Cup's final.

In 2005 it finally won its first international title, a Challenge Cup.

[2] The club has the record for most DHB-Pokals won with 9 titles, the latest being in 2010.