Artists included Bill Titcombe, John Canning, Neville Main, H. Watts, Gerry Haylock, Mike Lacey, and Steve Maher.

As well as Muffin the Mule (which ran for nearly 10 years—as the cover feature until 1955, then later as a half-page in black and white), other favourites from the 1950s that made appearances were Sooty, Coco the Clown, Noddy and Lenny the Lion.

As the decade passed, so the comic began to acquire a slightly more "grown-up" feel, with stories such as Treasure Island, The Lone Ranger and Black Beauty all appearing for a time.

As well as Doctor Who and Anderson strips, other highly collectable material included Telegoons (which ran from 1963 to 1967), Space Patrol (from 1964 to 1965) and The Avengers (based on the TV series featuring John Steed; initially from 1965 to 1966 and again from 1968 to 1972).

The only notable, collectable and original strips during TV Comic's latter years are arguably Battle of the Planets (drawn by former Dan Dare artist Keith Watson); these ran from 1981 to 1983.

This relaunch clearly failed to attract the sales increases that had been hoped; the comic dropped first "New" and then "Mighty" from the masthead after several months and reverted to a standard size (from issue 1,377) two years later.

While the overall production quality eventually improved, the comic continued to rely heavily on reprints of older material, or re-using scripts from old strips with new characters.

TV Comic also faced the long-term challenge of serving an often remarkably diverse readership in terms of both age and interests, finding itself running strips about anthropomorphised animals (clearly aimed at younger children, and based on properties already years old at the time) alongside adaptations of action adventure shows more popular with teenagers.

TV Comic was succeeded by Poylstyle's BEEB, a weekly, children's magazine focused specifically on the BBC's most popular programmes at the time and – somewhat belatedly – promoted as a BBC-orientated "answer" to ITV-focused Look-in.