[medical citation needed] Presentations differ among causes, but T cell insufficiency generally manifests as unusually severe common viral infections (respiratory syncytial virus, rotavirus), diarrhea, and eczematous or erythrodermatous rashes.

[1] Failure to thrive and cachexia are later signs of a T-cell deficiency.

[1] In terms of the normal mechanism of T cell we find that it is a type of white blood cell that has an important role in immunity, and is made from thymocytes.

[8] Also, intracellular fungal infections are also more common and severe in T cell deficiencies.

In terms of the management of T cell deficiency for those individuals with this condition the following can be applied:[2][1] In the U.S. this defect occurs in about 1 in 70,000, with the majority of cases presenting in early life.