In May 2003, the Tacoma Art Museum moved into a 50,000 square foot (4,650 m2) building located at 1701 Pacific Avenue, which was designed by Antoine Predock.

In designing the building, Predock drew inspiration from the region's light and its relationship to the water, Mount Rainier, the Thea Foss Waterway, and the neighborhood's industrial history and character in what is now known as the Tacoma Museum District.

[5] The expansion, which houses the Haub Family Collection of Western American Art, added approximately 16,000 square feet (1500 m2) to the museum.

[6][7] TAM's current Executive Director is Andy Maus[8] who began in 2023 one month before the museum board voluntarily recognized the employee organized union after heavy controversy.

[4] Nearly seventy percent of the collection consists of works from Northwest artists such as Guy Anderson, Morris Graves, Jacob Lawrence, Jared Pappas-Kelley, Akio Takamori, Mark Tobey, and Patti Warashina.