The Taipei Guest House (traditional Chinese: 臺北賓館; simplified Chinese: 台北宾馆; pinyin: Táiběi Bīnguǎn; Pe̍h-ōe-jī: Tâi-pak Pin-koán) is the historical building located at 1 Ketagalan Boulevard, Bo'ai Special Zone, Zhongzheng District, Taipei, Taiwan.

Gotō Shinpei was responsible for maintaining its construction budget, and was recalled to Japan to meet with National Diet members after it was reported that funds set aside for the Taiwan Grand Shrine were being spent on the Taipei Guest House.

After Taiwan was handed over to the Republic of China, ROC Minister of Foreign Affairs George Yeh and Japanese Minister of Foreign Affairs Isao Kawada signed the Treaty of Taipei here in 1952.

Taipei Guest House is open to the public on the first Sunday of even-numbered months from 4 June 2006.

The building is accessible within walking distance south east of NTU Hospital Station of Taipei Metro.