The Taipei Liaison Office in the Republic of South Africa (Chinese: 駐南非共和國台北聯絡代表處; pinyin: Zhù Nánfēi Gònghéguó Táiběi Liánluò Dàibiǎo Chù) represents the interests of Taiwan in South Africa in the absence of formal diplomatic relations, functioning as a de facto embassy.

Its counterpart in Taiwan is the Liaison Office of the Republic of South Africa in Taipei.

[3] However, when South Africa recognised the People's Republic of China, its diplomatic relations with Taiwan were terminated.

[5] The Office has responsibility for the interests of Taiwan in other African countries, such as Mauritius, Madagascar, Seychelles, Comoros, Kenya, Uganda, Malawi, Tanzania, Zambia, Somalia, Rwanda, Burundi, Eritrea, Angola, Zimbabwe, Botswana and Lesotho, as well as the French overseas region of Réunion.

[6] Taiwan previously had diplomatic relations with Malawi, and was represented in the country by the Embassy of the Republic of China in Lilongwe.