In light of the Russian border forces' withdrawal from the Tajik–Afghan border, the U.S. Government leads an international donor effort to enhance Tajikistan's territorial integrity, prevent the transit of narcotics and material or technology related to weapons of mass destruction (WMD), and support a stable, peaceful Tajikistan in order to prevent the spread of influence and activities of radical groups and terrorists.

They continue to assist Tajikistan on economic reforms and integration into the broader global marketplace, for example in pursuing World Trade Organization (WTO) accession.

A U.S. Government-funded $36 million bridge over the Panj River connects Sher Khan Bandar in Afghanistan with Nizhniy Pyanzh in Tajikistan, which transport more than 150 trucks or 1,000 cars daily.

The bridge enhance economic and commercial opportunities on both sides of the river, allowing goods and people to move across more easily.

The United States recognized Tajikistan on December 26, 1991, the day the U.S.S.R. dissolved, and opened a temporary Embassy in a hotel in the capital, Dushanbe, in March 1992.