Tajikistan sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016.

Tajikistan was represented by a single athlete in Rio de Janeiro: sprinter Romikhudo Dodikhudoev.

This made Rio de Janeiro the country's fourth appearance at a Summer Paralympiad.

[2] Tajikistan sent just one athlete to the Rio de Janeiro Paralympics: sprinter Romikhudo Dodikhudoev.

[12] As with his previous event, only the top eight progressed to the final, and Dodikhudoev's competition came to an end as he ranked 14th overall out of 17 finishers.