Takata was the family name of the mother of Matsudaira Tadateru (the sixth son of Iemitsu's grandfather, the previous shogun Tokugawa Ieyasu) who favored the area as a sightseeing spot.
During the morning rush hour, Takadanobaba is one of the hot-points of the Tokyo transport network with all three stations bursting at the seams with local residents, students and commuters.
In addition to serving students commuting to Waseda University, the area is home to many educational institutions including vocational colleges and preparatory schools.
[1] Also, many lamp posts in the area carry pictures from the TV series, and two large murals depicting Tezuka's works are across the street of JR Takadanobaba station.
Director J. J. Abrams referenced Takadanobaba as an influence on the naming of planet Takodana in the film, Star Wars: The Force Awakens.