His first manga series, Afro Samurai, was first published as a dōjinshi in the preparatory issue zero of the magazine, and was featured as the cover.

[needs update] On November 23, 2004, Okazaki wrote and illustrated a 9-panel manga published in the pamphlet of the Blade: Trinity soundtrack.

[7] Takashi Okazaki also illustrated the ending of the Cho-Kōryu-Gōjin Danke Choen (超交流合神ダンケシェーン) series serialized in a flyer handed out at the Japanese club "UNIT".

In April 2020, Okazaki made his debut as a Marvel Comics cover artist for the re-launch of Werewolf By Night.

[12] He also designed art for cards used in the Diamond Dynasty game mode of MLB The Show 22, including many Baseball Hall of Fame players such as Randy Johnson, Babe Ruth, Ken Griffey Jr, Rickey Henderson and Honus Wagner.