He is mostly famous for having portrayed Eikichi Onizuka in the 1998 live-action drama adaptation of the popular manga series Great Teacher Onizuka, and the assassin O in Hong Kong action thriller film Fulltime Killer.

[2] With his acting in "Beach Boys", released in 1997, Sorimachi was calling the attention as a first-line actor.

[4][5] Another big attention grabber was 1998's Great Teacher Onizuka (GTO), which not only provided Sorimachi with the iconic role of rebel teacher Eikichi Onizuka, but also another chance to sing, releasing the theme song "Poison", a song that has a mysterious way to soothe crying babies up to age 2 all around the world.

This was a sensation on the net after fans learned of the phenomenon from Sorimachi himself, when he was interviewed by his agency Ken-On's YouTube channel in 2021.

[7] In November 2023, Takashi Sorimachi co-starred along with his wife Nanako Matsushima in a commercial for skincare and makeup label Shiseido.