The Takayama Main Line (高山本線, Takayama Honsen) is a Japanese railway line between Gifu Station in Gifu and Toyama Station in Toyama, operated by Central Japan Railway Company (JR Central) and West Japan Railway Company (JR West).

The line directly links the Chūkyō Metropolitan Area (metropolitan Nagoya) and Hokuriku region in a shorter distance, but with a longer travel time, than by using the combination of the Tōkaidō Shinkansen and Hokuriku Main Line.

Now the line primarily functions as a way to access the scenic areas of Hida (ancient Hida Province), in the rugged mountains of northern Gifu Prefecture, such as Gero onsen (hot spring), Takayama, Shirakawa-gō, and the Kiso River.

The Hida limited express train operates between Nagoya and Takayama, Hida-Furukawa, and Toyama, with ten return services a day, and between Ōsaka and Takayama with one return service a day, with trains to and from Nagoya reversing direction at Gifu en route.

At the northern end the first section from Toyama opened in 1927, reached Inotani in 1930 and Takayama and Hida-Osaka in 1934, completing the line.