Take Charge Lady is a bay mare with a white star bred in Kentucky by William Schettine, the owner of the Florida-based Signature Stallions stud.
Four weeks later Take Charge Lady was moved up in class distance and started at odds of 5.8/1 for the Grade II Alcibiades Stakes over eight and a half furlong at Keeneland.
[9] Take Charge Lady was stepped up again on 27 October for the Breeders' Cup Juvenile Fillies at Belmont Park and was made the 11/1 fourth choice in the betting behind the Frizette Stakes winner You, Bella Bellucci and Habibti.
[10] On her final appearance of the season, the filly started favorite for the Grade II Golden Rod Stakes at Churchill Downs but was beaten four and a half lengths by the Carl Nafzger-trained Belterra, to whom she was conceding five pounds.
[14] On April 6 the filly was moved back into Grade I class and faced a rematch with Belterra in the Ashland Stakes (a trial race for the Kentucky Oaks) at Keeneland.
[20] After a break of three and a half months, Take Charge Lady returned in September in the Grade I Gazelle Stakes over nine furlongs at Belmont Park in which she was ridden for the first time by Edgar Prado who became her regular jockey.
Prado restrained the filly on the inside rail before moving up on the final turn to take the lead from You and took a clear advantage in the stretch to win by two and a half lengths from her fellow three-year-old with the five-year-old Chilean mare Printemps in third.
Drawn on the outside of the eight-runner field she raced in third place but tired in the closing stages to finish sixth behind the favorite Azeri beaten more than thirteen lengths by the winner.
[23] On November 28 she started odds-on favorite under top weight of 122 pounds for the Falls City Handicap at Churchill Downs but was beaten one and quarter lengths by Allamerican Bertie.
Take Charge Lady ended her season in the ungraded NTRA Great State Challenge Distaff Invitational Stakes at Sam Houston Race Park in Texas.
[24] On her first appearance as a four-year-old, Take Charge Lady was ridden for the first time by Shane Sellers (returning from a long injury layoff) when she contested the Grade I Apple Blossom Handicap at Oaklawn on April 5.
After a two and a half month break partly necessitated by a training injury at Churchill Downs in May[25] the filly returned in the Grade I Ogden Phipps Handicap at Belmont Park on 21 June in which she was re-united with Prado.
[26] A month later she was dropped in class for the Delaware Handicap (then a Grade II race) and finished second for the third time running, beaten six lengths by the Chilean filly Wild Spirit after leading until the last quarter mile.
"[27] On October 5 at Keeneland, Take Charge Lady attempted to become the fourth horse after Bornastar, Susan's Girl and Bayakoa to win the Spinster Stakes for a second time.
After racing just behind the leaders, Prado sent the filly into the lead on the penultimate turn, opened up a clear advantage entering the straight and held off the renewed challenge of You to win by a head, with a gap of four lengths back to Miss Linda in third place.
[29] Three weeks later Take Charge Lady made her second bid to win the Breeders' Cup Distaff, which was run that year at Santa Anita Park and started the 8/1 fourth choice in the betting behind Sightseek, Got Koko and Elloluv.