In a readers poll, Rolling Stone ranked "Take Me Home" number five on their list of ten best Collins songs.

[4] The song lyrics refer to a patient in a mental institution[5] and it is influenced by the Ken Kesey novel One Flew Over the Cuckoo's Nest.

The music video, directed by Jim Yukich and produced by Paul Flattery,[7] features Collins getting into a Ford Popular and singing a line of the song in various places around the world, including London, Paris, Tokyo, New York City, Sydney, Bremen, Memphis (Graceland), Los Angeles (Hollywood),[8] Stockholm, San Francisco, Kyoto, Chicago, St. Louis and Houston.

[10] David Fricke of Rolling Stone said that the song had "engaging, circular rhythm and languid melodic texture".

[16][17] "Take Me Home" appeared on the Phil Collins tribute album Urban Renewal, as performed by Malik Pendleton.

The cover, which features production from Da Internz, was praised for JoJo's vocals and the incorporation of trap and 808 beats.

"The clear standout is her version of Phil Collins’ 'Take Me Home,' all militant stomp buried under ambient noise," said Sam Lansky of Time magazine.

[20] Little Big Town and Sugarland covered this song to honor LBT's 25th anniversary as a band, and they performed it on the 2024 CMT Music Awards.