A fourth installment, Armistead Maupin's Tales of the City, premiered on Netflix on June 7, 2019, with Laura Linney, Olympia Dukakis, Barbara Garrick and Paul Gross reprising their roles.

[1] Following the storyline in Maupin's first book, the first miniseries begins in the summer of 1976, following Mary Ann's decision to remain permanently in San Francisco following her vacation there and spans the next several months, concluding on New Year's Day 1977.

Amid the controversy surrounding the homosexual themes, nudity, and illicit drug use in the miniseries, Tales of the City gave PBS its highest ratings ever for a dramatic programme.

In deference to local standards, PBS gave stations the option of showing an edited version in which male and female body parts were obscured by pixelation.

In the face of the rising AIDS epidemic and a changing social climate in the conservative Reagan era, HBO reportedly felt that the book's celebratory attitude toward homosexuality, casual sex and marijuana usage would not be deemed acceptable by the viewing public.

In More Tales of the City, Paul Hopkins was cast in the role of Mouse, Whip Hubley played Brian, and Nina Siemaszko was Mona.

In More Tales of the City, Mona discovers her true heritage when she winds up in a brothel in Nevada, run by Mother Mucca (Jackie Burroughs); on a cruise to Mexico with a lovelorn Michael, Mary Ann falls in love with Burke, a man without a past; DeDe decides to have her babies, much to Beauchamp's chagrin, and meets D'orothea; and Brian begins a rooftop dalliance with a mysterious woman.

In Further Tales of the City, Mary Ann has landed a job at a local TV station and finds a story that might make her a reporter; Frannie mourns the apparent loss of her daughter DeDe and grandchildren in the tragedy at Jonestown, until she makes a shocking discovery; Michael dates several men, including a cop, a cowboy, and a movie star; and Prue falls in a love with a mysterious stranger living in a shack in Golden Gate Park.

In the miniseries, Mother Mucca visits and introduces Mrs. Madrigal to a handsome, older man, a story line that does not exist in the books but was added for television.

The limited series starred Linney, Garrick and Dukakis reprising their roles of Mary Ann Singleton, DeDe Halycon Day and Anna Madrigal, respectively.