Micah Abbey, Shamon Brown Jr., Nicolas Cantu, Brady Noon, and Ayo Edebiri reprise their voice roles from Mutant Mayhem.

During production on the film, its producers Seth Rogen and Evan Goldberg were granted approval to develop a canon streaming television series.

[17] In July 2023, Variety reported that a film sequel and a 2D animated television series follow-up for Mutant Mayhem had been greenlit.

[18] Lukas Williams was set to oversee production for Point Grey Pictures which co-produces with Nickelodeon Animation Studio.

[21] Along with the series' announcement in July 2023, Micah Abbey, Shamon Brown Jr., Nicolas Cantu, and Brady Noon were confirmed to reprise their voice roles from Mutant Mayhem as the four Turtles.

[21] In June 2024, Alanna Ubach and Pete Davidson were confirmed to guest star in the series as Bishop and Rod respectively.

[13] In July 2024, Rose Byrne, Natasia Demetriou, and Post Malone were confirmed to reprise their roles as Leatherhead, Wingnut, and Ray Fillet.

[3][22] Christopher Mintz-Plasse, Timothy Olyphant, Jillian Bell, and Danny Trejo were announced to play new characters, Pigeon Pete, Goldfin, Lee the Eel, and Mustang Sally.

[23] Splinter, who was previously voiced by Jackie Chan in Mutant Mayhem, only speaks in a gibberish language called "vermin" in Tales.

[23] The showrunner felt the series' more crude art style helped to distinguish it from its more clean-looking action cartoon peers.

[25] Wan also felt that the art style paid homage to the original Turtles comics by Kevin Eastman and Peter Laird.

[41] Tyler Robertson of IGN gave the series an 8 out of 10 rating, praising the voice performances, animation, and action but criticizing the pacing and "downgrade" in the score and soundtrack.

[43] Tim Stevens of The Spool gave the series a 7.2 out of 10 rating, referring to it as a "decent Saturday morning-type spinoff of Mutant Mayhem".

She commended the animation, action, character work, and familial themes, though felt the show was limited by its younger skewing target audience.

[45] Sayantan Gayen of Comic Book Resources gave the series a 9 out of 10 rating, praising it for its worldbuilding, character work, animation, and heart.