The historic Creek peoples in this area are believed to have descended from the Mississippian culture, which flourished throughout the Mississippi and Ohio river valleys and the Southeast from about 1000 to 1450.

Trying to intercept a Red Sticks party who were bringing back arms thought to be purchased from the Spanish in Florida,[3] United States Army forces attacked the Creek at the Battle of Burnt Corn.

In retaliation, the next month the Red Sticks attacked Fort Mims, about 35 miles north of Mobile, Alabama, killing most of the more than 500 settlers and mixed-race Lower Creek who had taken refuge there.

Osceola is believed to have been born in Talisi, to a mixed-race Creek mother and an English father.

The Creek Wars (1813–1814) were marked by mutual raids, civilian massacres, and scalpings by both sides.

Led by then-General Andrew Jackson, a coalition of militia from Alabama, Tennessee and Georgia, federal troops, Lower Creek, and Cherokee crushed the outnumbered and out-gunned Red Sticks.

Jackson counted the conflict as among his politically strategic victories; it increased his popularity for later election to the presidency and his future policies of Indian removal.

The Creek who relocated from the Tuckabatchee area named a new settlement Talisi in Indian Territory.

[4] "Tallassee sent her fair share, and more, of her sons to fight for the Confederacy and a Tallassee textile manufacturer, Barnett, Micou, and Company, supplied cloth for Confederate uniforms and tents, leased land and a building for production of a Confederate carbine, and produced supplies, laborers, and rations for the Armory, its employees, and officers.

"[5] In June 1864 the Confederate army moved the Richmond Carbine Factory from Virginia to an old Tallassee cotton mill.

[6] Early in the morning of November 30, 2009, the historic Hotel Talisi was heavily damaged by a fire.

However, the building remains a crumbling eyesore as Tallassee's downtown begins to revive around it as of 2021.

"[7] "Child labor was common in the Tallassee Mills, as in thousands of American industrial plants, until the 1930s.

"[8] "The Houses on King Street, numbered 1, 3, and 5, today occupied by Ray Carr, Houston Blount, and Frazier Elliot, were built about 1863 for the families of the confederate officers in charge of the armory and those in charge of the mill.

"The Tallassee National Guard Company served in World War I, and a community library was established in 1921.

During WWII, the mills received awards of excellence from the U.S. Army for production of war materials.

Visitors who are unacquainted with Tallassee custom are sometimes startled by being awakened by the sound of the bell.

Their sons, Thomas M., Jr. and Nicholas, lived in Tallassee, building homes on the hill above the mill.

After completing his eligibility he moved with his wife Mary Carroll to Tallassee, where he worked at Mount Vernon Mills.

Payne won in a highly contested race against incumbent Thomas Pollard.

Hammock - after his first term - focused on fixing the town's crumbling infrastructure that had been long neglected.

From 2016-2020 Hammock, along with a progressive council, brought in grants and funding totaling in the millions to help address the issues previously left unresolved by past administrations.

Tallassee is located in the densely forested Emerald Mountains, a small southeastern chain of the Lower Appalachians.

As of the 2020 United States census, there were 4,763 people, 1,905 households, and 1,247 families residing in the city.

[20] The Community Hospital, established in 1926, provides healthcare to the surrounding three counties (Elmore, Tallapoosa, and Macon).

[21] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

In addition to maintaining these facilities, the recreation department also offers and sponsors numerous youth sports and adult activities.