It is separated from the Cordillera de Mérida in the Venezuelan Andes by the Táchira depression, which more than 50 million years ago was a strait that connected Lake Maracaibo with the Orinoco basin.

[5] The páramos give rise to rivers such as the Carapo, Chiquito, Quinimarí, Quite, Burguita, Burga, Nula, Nulital, Sarare, Cutufí, Oirá, Frío and Negro, which drain into the Orinoco basin or into Lake Maracaibo.

The Táchira River, which drains into Lake Maracaibo, forms part of the border between Colombia and Venezuela.

In the páramos the plant species are of the genera Jamesonia, Oreobulus, Castilleja, Gentiana, Halenia, Pinguicula, Utricularia, Castratella and Vaccinium.

The endemic wood sprite gracile opossum (Gracilinanus dryas) and Luis Manuel's tailless bat (Anoura luismanueli) are found in both the Andean Cordillera and the Tamá Massif.