[7] Notable flora include: Weinmannia pubescens, Wettinia microcarpa, Befaria glauca, Mexican alder and endemic Espeletia uribei which grows higher than metres.

[5] The fauna is varied, notable mammals found in the area include: spectacled bear, opossum, deer, mountain lion and anteater.

Notable birds include: oilbird, endangered northern helmeted curassow and flame-winged parakeet, a species endemic to the region.

[8][9] The water resources generated in the Tamá National Park are of interest for the economic and social development of the departments of Norte de Santander and Arauca in Colombia and the states of Táchira and Apure in Venezuela.

The Tamá National Park water complex benefits the communities in agricultural activities and in the supply of water for the communal and municipal aqueducts, and supplies the demand of more than 2,000,000 inhabitants located in territories of the states of Apure and Táchira in Venezuela and of the departments of Norte de Santander, Boyacá and Arauca in Colombia.