Tamazunchale is a town and municipality in the Mexican state of San Luis Potosí, central Mexico.

[3] The area of the State of San Luis Potosí including: Tamazunchale, Jacala, Coxcatlan, Tamacuil, Xatxapala, Tacetuco and Huahuatla along the Moctezuma River, was the Huastec Indian territory.

In 1485, the three chiefs of the Huastec nation, Chicontepec, Temapache, and Molango, led several rebellions and were free for a time from the Aztecs.

Then they went up river to Panuco and helped Fransico de Garay, who had been on an earlier expedition to that area; 100 of his men had been killed by the Huastecs there, and 200 more elsewhere.

[7] For tourists driving from the United States, Tamazunchale has long been a prominent overnight stop en route to Mexico City.