Tangier Sound is a sound of the Chesapeake Bay bounded on the west by Tangier Island in Virginia, and Smith Island and South Marsh Island in Maryland, by Deal Island in Maryland on the north, and the mainland of the Eastern Shore of Maryland and Pocomoke Sound on the east.

Crisfield, Maryland, located on Tangier Sound, is a center of the shellfish industry.

As in other parts of Chesapeake Bay, the seafood industry on Tangier Sound has declined markedly due to pollution, mismanagement and the growth of recreational fishing.

However, the wild oyster industry has seen a strong reemergence in recent years due to shell planting and caretaking methods performed by Chesapeake watermen.

Tangier Sound is considered by many to possess the best oysters and soft crabs in the world.