The series is based on the 2010 film Tangled and features the returning voices of Mandy Moore and Zachary Levi, alongside Eden Espinosa, Clancy Brown, Julie Bowen, James Monroe Iglehart, Jeff Ross, Paul F. Tompkins, and Jeremy Jordan.

[3][4] Six months after escaping Mother Gothel and reuniting with her birth parents, King Frederic and Queen Arianna of Corona, Princess Rapunzel is unable to properly adjust due to her father's constant protection.

When she and her handmaiden Cassandra sneak out of the castle, they come upon some black rock spikes that magically restore Rapunzel's long blonde hair.

Rapunzel, Cassandra, Eugene Fitzherbert, Pascal the chameleon, Maximus the horse, and a young alchemist named Varian uncover the mystery of her hair's return and its connection to the black rocks growing around Corona.

During the journey, Rapunzel gets the chance to explore the world and learns the origins of the Sundrop and Moonstone as two halves of an ancient power seeking to be rejoined.

Klaudia Amenábar of The Mary Sue argues that the show has "relatable themes" for Millennials and those in Generation Z, with focus on emotional abuse, trauma, friendship, and creating relationships.

Amenábar also argued that Eugene represents "healthy and supportive masculinity", and described the series as a Millennial sitcom which parses out "uniquely adult issues for kids.".