A member of the Armagnac party, he became a leading adviser of King Charles VII of France, and was one of the murderers of Duke John the Fearless of Burgundy in 1419.
He opposed the partisans of the duke of Burgundy in their attempts to capture Paris.
He was a favourite of Charles the Dauphin (later Charles VII), whom he saved by taking him out of Paris to Melun at the time of the invasion of Paris by the Burgundians led by Jean de Villiers de l'Isle-Adam during the night of 28–29 May 1418.
Also, in 1429, he used all his effort to convince the Dauphin to receive and welcome Joan of Arc – in effect, several of Charles VII's counsellors supported the principle of a rapprochement with Burgundy in order to present a united front against England, which could not have been achieved without du Chastel's efforts.
He next was in the service of king Louis XI of France, and was killed in 1477 at the siege of Bouchain in Picardy, in the course of a war against the Duchy of Burgundy, after the death of Charles the Bold.