She served as the state secretary in the ministry of defence from 2010 to 2012, and was appointed director of the negotiating team regarding the accession of Serbia to the European Union in 2013.

As the director, she emphasised on harmonising Serbia's foreign policy positions with the European Union and worked on implementing the reforms into law.

She resigned from the role in 2019, after which she began working as deputy secretary general of Regional Cooperation Council until her appointment in the third cabinet of Ana Brnabić in October 2022.

[1][4] Miščević began her work at the Faculty of Political Sciences at the University of Belgrade in 1991 as a demonstrator for the English language, a role which she held until 1995, when she became an intern assistant.

[5] Additionally, she was a visiting professor at the Military Academy of the Ministry of Defense and the Centre for European Integration at the University of Bonn.

[4] She was one of the founding members of the G17 Institute, a non-governmental organisation later-turned political party, where she worked as a manager for the department of European studies.

[10] She received the "Rainbow" award from the Gay Straight Alliance due to her contribution for the fight against homophobia and improving rights of the LGBT population.

[19] Miščević advocates for the accession of Serbia to the European Union,[12][20] citing her support for a "modern, stable, and developed society, and equality".