During this time Tagaq, like most other students from the central Arctic lived at Akaitcho Hall, the residential facility for Sir John Franklin High School.

[17] In May 2018, Tagaq announced her first book, a blend of fiction and memoir titled Split Tooth, which was published in September 2018 by Penguin Random House.

[23] In 2005, Tagaq collaborated with Okna Tsahan Zam, a Kalmyk Khoomei throat singer, and Wimme, a Sami yoiker from Finland, to release the recording Shaman Voices.

Tagaq collaborated with composer Derek Charke, percussionist Jean Martin and violinist Jesse Zubot, and the work was performed at the 2012 TIFF and Under the Radar Festival at New York's Public Theater, 2016, amongst other places.

In March 2014, Ellen DeGeneres donated $1.5 million to the Humane Society of the United States, an outspoken critic of the Canadian seal hunt.

As part of this viral media campaign, Tagaq posted a picture of her young daughter lying beside a dead seal on Twitter.

The seal had been killed to feed a group of local elders and is an essential part of an Inuk diet, eaten by necessity and tradition.

[30][31] During her Polaris Music Prize acceptance speech, she encouraged people to wear and eat seal, and shouted, "Fuck PETA",[32] which enraged animal rights activists.

Subsequently, Tagaq tweeted, "I had a scrolling screen of 1200 missing and murdered indigenous women at the Polaris gala but people are losing their minds over seals.

The list praised Tagaq's activism against "to expose hard truths about systemic racism in governments, missing and murdered Indigenous women and proudly supporting the practices and preservation of her culture such as seal hunting.

"[36] In 2020 she provided narration in the music video for "End of the Road", a protest song about the issue of missing and murdered Indigenous women by the rock band Crown Lands.