He was director of the Issam Fares Institute on Public Policy and International Affairs at the American University of Beirut (2014–2019).

Previously, he worked in the World Council of Churches in Geneva and held various positions in ecumenical organizations, responsible of Christian-Muslim relations, intercultural and interreligious dialogue.

He authored a number of books and articles on contemporary Arab issues, religion and politics, interreligious and intercultural dialogue.

On January 2025, Al Jadeed TV reported he is to serve as Deputy Prime Minister in the new Lebanese governmet.

[6] Mitri states his role is more as an advocate for the intellectuals and the artists along with their freedom of expression and thought.