[3] In an effort to avoid wasting COVID vaccines on the verge of expiring, Khan took it upon himself to individually visit and inoculate over 900 homebound residents in Philadelphia.

[9][10][11] Khan's delivery of "angel doses" garnered him national media attention and resulted in the establishment of a mobile vaccine clinic and more in-home inoculations.

[13] His political activism and advocacy has included supporting the passage of the Affordable Care Act, advocating for universal pre-kindergarten in Philadelphia, and opposing the construction of a gas plant in Nicetown, Pennsylvania.

[13] In 2022, Khan defeated incumbent Pennsylvania State Representative Pam DeLissio from the 194th District in a Democratic primary challenge.

[16] In 2024, Khan led a group of Pennsylvania lawmakers to propose a bill to outlaw the use of deepfakes by political campaigns.