He played college football at Southern Miss, and was selected by the San Francisco 49ers in the third round of the 2018 NFL draft.

Moore played two years at Pearl River Community College before transferring to the University of Southern Mississippi.

Moore signed with Southern Miss over other schools including Arkansas State, Louisville, Middle Tennessee, Minnesota and Nebraska.

At the conclusion of the pre-draft process, Moore was projected to be a third round pick by NFL draft experts and scouts.

[11] In Super Bowl LIV against the Kansas City Chiefs, Moore recorded an interception off a pass thrown by Patrick Mahomes which was deflected off the arm of wide receiver Tyreek Hill during the 31–20 loss.