Mitropoulos was born in Volos, and started his football career at local team Aris Petroupoli.

Mitropoulos later played two seasons for AEK Athens, winning two league titles with them, and for Olympiacos' fierce rivals Panathinaikos, albeit only one game.

Mitropoulos was also a prominent Greece national team player between 1978 and 1994, playing 76 matches and scoring 8 goals.

After retiring from playing in 1998, Mitropoulos became an assistant coach to Dusan Bajevic, Alberto Bigon, Yannis Matzourakis and Takis Lemonis in Olympiacos.

After retiring, Mitropoulos became a politician serving in the Piraeus city council.