Paul Marin de la Malgue's allied force who was en route from Annapolis Royal to Louisbourg.

[6] The homes of the Acadians who lived in the village were burned as part of the Bay of Fundy Campaign (1755) during the French and Indian War.

Tatamagouche and nearby Wallace, Nova Scotia were the first villages in Acadia to be burned because they were the gateway through which Acadians supplied the French Fortress Louisbourg.

Low land prices in other colonies made attracting tenants difficult, but an offer of six years free rent to dissatisfied residents of Lunenburg was a moderate success in 1772.

There the Scottish merchant John Dick was recruiting colonists and shipping them across the English Channel to be transported to Halifax, Nova Scotia.

Many of the larger vessels, such as the brigs, barques and brigantines, were loaded with lumber from the area and sailed to Britain, where first the cargo, and then the ship itself, were sold.

On May 17, 1824, Alexander Campbell and partners William Mortimer and G. Smith launched their first ship on the French river, a 63-foot (19 m) schooner named Elizabeth.

The ICR commissioned the Rhodes Curry Company of Amherst to build a passenger station in the village immediately east of the creamery.

The ICR was merged into the Canadian National Railways in 1918 and CN operated this line as part of its "Oxford Subdivision", servicing mainly agricultural communities, as well as the salt mines at Malagash and Pugwash as well as a quarry in Wallace.

Passenger service through Tatamagouche was discontinued in the 1960s and the station was used as an office for railway employees handling freight until 1972 when it was closed and sold in 1976.

Ron Joyce, Canadian entrepreneur, billionaire and co-founder of Tim Hortons was born in 1930 in Tatamagouche, Nova Scotia.

In September 2008, Paperny Films of Vancouver, British Columbia, Canada selected Tatamagouche as the venue for the second (and last) season of The Week the Women Went.