She was heavily involved with the politics of the Romanov court during the reigns of her brother Alexis and the regency of her niece Sophia.
During the regency of her niece Sophia, she reportedly exercised some degree of influence at court, where she was treated as the senior female member at court in etiquette matters and given precedence by regent Sophia before the dowager Tsaritsa Natalya.
When Sophia was deposed by tsar Peter the Great in 1689, Foy de la Neuville reported that Sophia sent her sister, Tsarevna Marfa, and aunts, Anna and Tatyana, to mediate.
Tatyana died in the early hours of 24 August 1706, and was interred at Ascension Convent near the Spassky Gate in Moscow on the same day.
[4] When archaeologists opened her sarcophagus, her body was found dressed in green Chinese silks.