[3] Preston made her WTA Tour main-draw debut in doubles at the Melbourne Summer Set 2, where she received a wildcard partnering Alexandra Osborne.

[4][5] She made her WTA Tour main-draw debut in singles at the 2022 Rosmalen Grass Court Championships as a qualifier.

[9] Later that month at the San Diego Open, having been given a wildcard entry, she defeated world number 42 Magdalena Fręch to win her first Tour level match and also her first against a player ranked in the Women's Tennis Association top 50.

[12] Preston was given a wildcard entry to make her maiden appearance at the US Open in August but lost in the first round to 25th seed Anastasia Pavlyuchenkova.

[13] Partnering Maya Joint, Preston won her first WTA 125 doubles title at the Cancún Open, defeating Aliona Bolsova and Yvonne Cavallé Reimers in the final.