He signed with the Blue Jays and made his professional debut with the Vancouver Canadians, making 11 appearances (8 starts) in 2011 and posting a 1–3 win–loss record, 5.88 ERA, and 25 strikeouts in 332⁄3 innings.

[3] Cole played the entire 2012 season in Vancouver and greatly improved, posting a 6–0 record, 0.81 ERA, and 57 strikeouts in 661⁄3 innings.

[6] Cole played the entire 2015 season with New Hampshire, pitching to a 7–10 record, 4.06 ERA, and 128 strikeouts in a career-high 164 innings.

[8] He made his debut on August 9, pitching one inning of the Blue Jays' 11–5 loss to the New York Yankees.

[11] Cole signed a minor-league contract with the Blue Jays on August 18,[12] and was added to the 40-man roster on September 29.

On January 19, 2022, Cole signed a minor league contract with the Boston Red Sox that included an invitation to Spring Training.

On July 14, 2022, Cole signed with the Tecolotes de los Dos Laredos of the Mexican League.