After scoring 75 points in 68 games in his second OHL season, Pyatt was selected eighth overall in the 1999 NHL Entry Draft by the New York Islanders.

Pyatt benefitted from playing on the Canucks' top line with twins Henrik and Daniel Sedin,[3] leading to career highs in goals and points, with 23 and 37 respectively.

Getting in the way of an Eric Brewer clearing attempt in a game against the St. Louis Blues, he required 25 stitches in his upper lip and a splint in his mouth to hold up his teeth.

Despite being taken off the Canucks' top line with the Sedins during the season, Pyatt completed the campaign matching his career-high of 37 points, as well as setting a new career mark for assists with 21.

[11] One month after returning to the Coyotes' lineup, he and younger brother Tom Pyatt of the Montreal Canadiens played against each other for the first time in their careers.

In the playoffs, he scored one goal and recorded one assist as the Coyotes were eliminated in the Western Conference Quarterfinals by the Detroit Red Wings in seven games.

[15] On June 21, 2010, Pyatt signed a two-year, $2 million contract extension with Phoenix, avoiding unrestricted free agency.

On July 24, 2014, with indication of little NHL interest, Pyatt agreed to a one-year free agent contract with Swiss team Genève-Servette HC of the National League A.