Written by a speech-language pathologist and a learning disabilities educator, Teaching with Calvin and Hobbes is a language textbook for elementary and intermediate-level students.

The five units are: In each unit, questions for comprehension and discussion follow the comic strips: In both the 1996 first edition and the 2006 second edition of their book How to Reach and Teach All Children in the Inclusive Classroom, teachers Sandra F. Rief and Julie A. Heimburge "highly recommend" Teaching with Calvin and Hobbes as an educational resource.

[3][4] Owing to Bill Watterson's principled refusal to license his comic strip for merchandise in general,[5][6] Teaching with Calvin and Hobbes is an exceptional item; a license was granted to the authors after they personally communicated to Watterson the success they had using his comic strip to teach children with learning disabilities.

[1][7] Published in a limited print run in Fargo, North Dakota,[1] Teaching with Calvin and Hobbes is a very rare and highly sought-after book.

But those can run up to $34,000 and are nearly impossible to find..." As of May 2023[update], WorldCat lists only eight libraries in the world as holding a copy of the book, including three in North Dakota, where the book was published, the United States Library of Congress, and educational institutions in Ohio, California, the United Arab Emirates, and Singapore.