is the trading name for North Wales Science, the charity operating the centre, and is fully owned by Wrexham University.

The building was formerly used by T. J. Hughes until 2011,[17] and sits at the edge of a then largely empty retail space, with the relocation of the centre hoped to regenerate the area.

[18] DAY Architectural conceived and delivered the project for Wrexham Glyndŵr University, with branding applied by Scan Stick.

[24] As of August 2022[update], the centre opens on Fridays and weekends, with extended times during Wrexham's school holiday period.

[26] In January 2014, the Welsh Government conducted a study into Techniquest's Cardiff and Wrexham sites, with both centres largely meeting their aims, although not consistently meeting government core grant targets, but also having a well-regarded brand, their perceived relevance to enhance STEM curricula by teachers, and their "strong" partnership networks with other STEM support providers and educational institutions.

Although branded both "Techniquest" both sites are operated separately by different charities, with the Wrexham site's ties to Glyndŵr University, as well as local industry and existing plans for long-term financial sustainability stated as reasons for the Wrexham branch to be better positioned in the event of a public funding cut.

[40] In February 2018, Techniquest Glyndŵr had signed a 12-month agreement with the owners, MCR Property Group, of the former TJ Hughes store in Henblas Square, as well as the local council and the university, to potentially occupy the building.

[1][40][42][46] On 23–25 August 2018, Techniquest Glyndŵr hosted a pop-up science event at the former TJ Hughes building on Henblas Street, collaborating with the Royal Air Force to celebrate its 100th anniversary.

The centre had hosted various pop-up events in the Henblas Street building on a short-term basis, maintaining its university site, but in May 2019 it applied to Wrexham County Borough Council stating it planned to make the relocation permanent.

[47][48][49] On 20 June 2019, Techniquest Glyndŵr's formally announced its plans to fully relocate to and buying the freehold of the Henblas Street site in Wrexham city centre.

[54] In October 2019, the centre partnered with Principality Building Society to launch a financial education programme for North Wales, Chester and Shrewsbury, delivering financial education lessons, including identifying money, how to save money and costing, to eleven local community schools by October 2019.

Funding for the £2.8 million was supported by UK Research and Innovation, the Department for Business, Energy and Industrial Strategy and the Wellcome Trust's Inspiring Science Fund (£1.75 million), Wrexham Glyndŵr University, and a local partnership, the Targeted Regeneration Investment programme, between Wrexham County Borough Council and the Welsh Government (£750,000).

One exhibit would be focused on what shouldn't be put down toilets or kitchen drains, and the other on configuring a pipe network for a house using blue water balls to then educate users the average amount of litres needed to complete many household tasks.

[65] On 7 December 2021, the centre was officially opened by a ribbon-cutting ceremony, which was unable to have taken place earlier due to public health restrictions related to the COVID-19 pandemic.

Staff, stakeholders and dignitaries attended the ceremony, with deputy mayor of Wrexham, Brian Cameron cutting the ribbon.

and St Giles' Church hosted a Wonder Day event, which included activities such as a stardome, electric circuit demonstrations and "mysteries of slime".