Edward M. O'Brien (born 1957) is an American politician who served in the New York State Senate in 2013 and 2014, representing District 55.

He entered into partnership with other attorneys to form Harris, Chesworth, O'Brien, Johnstone & Welch, LLP in 1991.

O'Brien began his political career as the chair of the Monroe County Democratic Committee.

In November 2012, he bested Sean Hanna for the state Senate seat left open by the retiring James Alesi.

[1] O'Brien lost his Senate seat to the Republican and former WHEC-TV anchor Rich Funke in the 2014 general election.