Formed in 2010, the band is led by married couple Susan Tedeschi and Derek Trucks.

[9] In 2013, the band was nominated for the Blues Music Awards[10] and released their third album, Made Up Mind.

[11] The band gave a Joe Cocker Mad Dogs and Englishmen tribute concert at the 2015 Lockn' Festival[12] featuring alumni musicians from that album including Leon Russell, Claudia Lennear and Dave Mason.

[17] The fourth studio album, Signs, was released on February 15, 2019, on Fantasy Records and Concord.

[20] On April 20, 2022, Tedeschi Trucks Band announced I Am the Moon, a quadruple album featuring 24 original songs which was released in four parts throughout the year, beginning with I. Crescent on June 3, II.