Among her other notable appointments, was her position as Pakistan's Representative to the United Nations in Geneva and as ambassador to Italy, with concurrent accreditation to Albania, San Marino and Slovenia.

[9] When her time as Counsellor in Geneva ended, she returned to Pakistan to serve as the Director Minister of State for Foreign Affairs' Office in 2000.

[11] The following year, her experience was utilized as Deputy Permanent Representative of Pakistan to the United Nations and Other International Organizations, in Geneva until 2009.

[12][13] As Spokesperson, Janjua provided important details of the safe return of Pakistanis from Libya, the on-going Indo-Pak talks and the drone strikes initiated by the United States during her term.

[20] In February 2017, Prime Minister Nawaz Sharif appointed Janjua as Pakistan's Foreign Secretary, succeeding Aizaz Ahmad Chaudhry.