One of the richest Transylvanian collections of cultural artefacts, it was founded by the Hungarian Count Sámuel Teleki in 1802, at the time when Transylvania was part of the Habsburg monarchy, and has been open to the reading public ever since.
Its founder, Count Sámuel Teleki de Szék (1739–1822) was one of the most learned book collectors of the time.
From the very beginning, he intended his collection as a public library, and developed it throughout his life; he remained a committed and active bibliophile despite his time-consuming administrative career — he was Chancellor of Transylvania from 1791 until his death — building on his relations with all important European printing and publishing houses, and purchasing all important works published between the invention of the movable type and the early 19th century.
In order to publicize his library, Teleki compiled and published a four-volume catalogue (Vienna, 1796–1819), divided according to general topics.
According to the surviving accounts of the librarians, which contain the names and professions of the readers, as well as the authors and titles of the books read, the facility was attended by a sizable portion of the 6,000-7,000 citizens Târgu-Mureş had at the time.