Karamollaoğlu, who worked in the private sector for two years after his military service, served as the Incentive and Implementation General Manager of the Ministry of Industry and Technology in 1975.

Aziz Nesin's presentation of his Turkish translation of The Satanic Verses in Madımak Hotel in Sivas was controversial, and a mob of MHP supporters started a fire which killed many of the guests in attendance, most of whom were Alevi.

Karamollaoğlu's role in the Madımak Massacre is controversial, some claimed he urged the mob to disperse, other accounts allege that he endorsed their cause.

Following investigations of the Refah-Yol government, Karamollaoğlu’s brother and other officials at the state-run fertilizer firm TÜGSAŞ were prosecuted for siphoning off $20 million in gas.

He was a member of the "White Beard" faction, the orthodox Milli Görüş politicians that opposed the reformist "Innovators", led by Recep Tayyip Erdoğan.

At the Felicity Party congress held in May 2000, Karamollaoğlu was elected as a member of the general administrative board and was appointed as the vice president responsible for foreign affairs.