The institution hired 262 new professors in 4 years; added clinical and basic science departments; and completely revamped the medical curriculum to meet changing educational paradigms.

[6] The Medical Education Research Building also features a wide array of attributes designed to lower stress of its faculty, staff, and students.

The education of medical students at Temple University School of Medicine includes a foundation in the fundamentals of basic and clinical science.

The first two years are taught in an integrated approach, closely tying basic science concepts to clinical medicine, professionalism and medical ethics.

The first year is divided into seven blocks: A doctoring course running throughout the preclinical curriculum enables students to learn the basics of history-taking, physical exam skills, and professionalism.

Students learn these skills with the help of clinician preceptors who provide individualized real-time observational feedback as well as longitudinal mentoring and career advising.

The second year is divided into 5 blocks: The Doctoring 2 course enables students to practice and improve their clinical skills and professionalism through closely supervised rotations in both ambulatory and hospital settings.

The first of these branch campuses was established at St. Luke's Hospital, Bethlehem, Pennsylvania and opened in Fall of 2011 with an inaugural class of 30.

In August of 2024, LKSOM announced plans to establish a second branch campus in York County, Pennsylvania in partnership with Wellspan Health, with an inaugural class of approximately 40 students expected in 2027.