The Temptation of St. Thomas is a painting by the Spanish Baroque painter Diego Velázquez, executed in 1632 and housed in the Museum of Sacred Art of Orihuela Cathedral, southern Spain.

The work, for a period, was attributed to Murcian painter Nicolás de Villacis, until it was recognized as Velázquez's in the 1920s.

It portrays the episode of the life of Saint Thomas Aquinas when, as a novice, he resisted the temptation represented by a prostitute, who is visible in the background door.

The saint is held by an angel, while another is preparing to dress him with a white ribbon, representing chastity.

Temptation of St. Thomas is among Velázquez's better-known paintings.