Tennessee's 21st Senate district is one of 33 districts in the Tennessee Senate.

It has been represented by Democrat Jeff Yarbro, the current Senate Minority Leader, since 2014.

[2] District 21 is a convoluted district covering much of central Nashville and its inner suburbs in Davidson County, snaking its way from the Nations and Sylvan Park, down to Berry Hill and Grassmere, eastwards to the border of La Vergne.

Vanderbilt University and part of the Nashville International Airport is located within the district.

[4] Tennessee Senators are elected to staggered four-year terms, with odd-numbered districts holding elections in midterm years and even-numbered districts holding elections in presidential years.