[2] District 22 is based in Clarksville, and covers most of, Montgomery County.

Other communities in the district include Cunningham and Needmore.

[1] Tennessee Senators are elected to staggered four-year terms, with odd-numbered districts holding elections in midterm years and even-numbered districts holding elections in presidential years.

In November 2018, incumbent Mark Green was elected to Tennessee's 7th congressional district, leaving the 22nd Senate district open.

Former senator Rosalind Kurita was appointed as a caretaker until a special election for the seat could be held in April 2019.