It then goes north to enter Knoxville as a 4-lane (Lovell Road) and comes to an intersection with Parkside Drive, which provides access to the Turkey Creek shopping area.

SR 131 then leaves Karns and continues through the countryside of northern Knox County before entering Powell and having an intersection and becoming concurrent with US 25W/SR 9 (Clinton Highway).

They go southeast and cross Beaver Creek over a bridge and pass several businesses before SR 131 splits off onto Powell Drive.

They then enter another business district and come to another interchange with I-75 (Exit 112) before passing by North Knoxville Medical Center and more subdivisions before leaving Powell.

SR 131 then continues east (now as Mountain Valley Highway 131) through some more rolling farmland before crossing into Hancock County.