SR 14 begins concurrent to US 61 at the Mississippi state line in Shelby County.

It then goes through some more neighborhoods before passing through a business district, crossing a railroad overpass and having an interchange with I-55 (Exit 7).

US 61/SR 14 then pass through some more neighborhoods before coming to an intersection with E.H. Crump Boulevard (US 64/US 70/US 79/SR 1), at which point US 61 turns west along E.H. Crump Boulevard to become concurrent with I-55 and cross the Mississippi River into Arkansas while SR 14 continues north on S Third Street to become concurrent with US 64/US 70/US 79/SR 1 and enter downtown.

On Jackson Avenue, SR 14 passes through the "North Memphis" neighborhood and has another interchange with I-40/I-69 (Exit 1F).

It then continues through the neighborhood and passes by an industrial area before having its third and final interchange with I-40 (Exit 8 eastbound, Exit 8 A/B westbound) and transitioning from Jackson Avenue to Austin Peay Highway as it enters the neighborhood of "Raleigh".