SR 2 begins in Rutherford County in Murfreesboro as a secondary route where US 41 leaves a concurrency with US 70S/SR 1.

After entering Coffee County, the concurrency passes through the community of Beechgrove, and becomes Murfreesboro Highway.

They have an interchange with I-24 and continue into Manchester, becoming Hillsboro Blvd in downtown, and intersecting SR 53 (Woodbury Highway), which is also its southern terminus and it connects to Bradyville, then SR 55 (McArthur Street), which connects to McMinnville and Tullahoma, before intersecting I-24 once again and leaving town as Hillsboro Highway.

US 41/SR 2 then continue southeast, and paralleling I-24, they enter the community of Hillsboro and intersect SR 127 (Winchester Highway), which connects to Winchester and Viola, and then they go to the community of Pelham and intersect SR 50 (Payne Cove Road), which connects to Alatamont and Alto.

US 41 and SR 56 leave the concurrency and turn north as Fairmont Avenue before going northeast to Tracy City.

Once in Kimball, SR 2 becomes concurrent with US 64 (which leaves the interstate just shortly before this point) and US 72, which goes through South Pittsburg, and moves northeast through downtown Kimball as Main St and then continues northeast to Jasper as Lee Highway.

A short distance later, it intersects SR 28 (Valley View Highway), which connects to Sequatchie and Whitwell.

Another short distance later, they intersect SR 27 (Griffith Highway), which connects to Powells Crossroads before leaving Jasper.

The concurrency moves southeast once again as Lee Highway before crossing Nickajack Lake/Tennessee River on the Marion Memorial Bridge and turning north and entering Haletown and intersecting SR 134 (J E Clouse Highway), which connects to Whiteville and SR 156.

They then continue northeast, then south as the highway parallels the Tennessee River Gorge and works around Lookout Mountain.

US 11/SR 2 continues northeast as Congress Parkway and into Niota where it becomes Willson Street and intersects SR 309 (Union Grove Road), a connector to I-75.

Continuing as a primary state route, It then enters Sweetwater and intersects SR 68 at which point US 11/SR 2 becomes South Main Street.

In downtown Sweetwater, it changes to North Main Street and briefly turns north before turning northeast once again and intersects SR 322 (Oakland Road), a connector to I-75 and Vonore before leaving town as Lee Highway.

They then enter Loudon County and moves through the small town of Philadelphia, intersecting SR 323 (Pond Creek Road), a connector to I-75.

After crossing the river, US 11/SR 2 once again becomes Lee Highway and intersect SR 324 (Sugar Limb Road), a connector to I-75.